Retatrutide vs. Other Weight-Loss Drugs: How Does It Compare?
Retatrutide is part of a new generation of hormone-based weight-loss medications, but how does it stack up against semaglutide (Wegovy, Ozempic) and tirzepatide (Mounjaro)?
|
Name |
Mechanism of Action |
Avg. Weight Loss |
|
Retatrutide |
GLP-1 + GIP + Glucagon receptor agonist |
Up to 24% (48 weeks) |
|
Tirzepatide (Mounjaro) |
GLP-1 + GIP receptor agonist |
Up to 22.5% (72 weeks) |
|
Semaglutide (Wegovy/Ozempic) |
GLP-1 receptor agonist only |
Up to 15-17% (68 weeks) |
Key Differences
-
Weight Loss Effectiveness
- Buy Retatrutide shows the greatest weight loss (24%) so far, even more than tirzepatide and semaglutide.
- Tirzepatide is currently the most effective drug (22.5%) but slightly behind Retatrutide in trials.
- Semaglutide is still highly effective but less potent than the other two.
-
Mechanism of Action
- Retatrutide is unique because it adds glucagon activation, which increases fat burning and metabolism.
- Tirzepatide only activates GLP-1 and GIP, boosting insulin and reducing appetite.
- Semaglutide is GLP-1 only, focusing mostly on appetite suppression.
-
Side Effects
- Retatrutide may cause more nausea, vomiting, and possible muscle loss due to its stronger effect.
- Tirzepatide also has nausea but is usually tolerated well.
- Semaglutide has the fewest side effects but also the least weight loss.
Which One is Best?
- Retatrutide could be the most powerful weight-loss drug ever.
- Tirzepatide is the best currently available option for weight loss.
- Semaglutide is still effective and may have fewer side effects.
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